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Gene sleep

Not a medical test — for research and educational use only

Yeliztli analyses consumer genotyping-array data (23andMe / AncestryDNA), which is not a clinical-grade test. Results are not diagnostic, are not clinically validated, and must not be used to make medical decisions. Array data is especially unreliable for rare, disease-causing variants. Always confirm any finding with an accredited clinical laboratory and discuss it with a qualified clinician or genetic counsellor before acting on it. See the Intended use & disclaimers page for the details and the evidence behind this warning.

The sleep module gives a categorical read on caffeine metabolism, sleep quality, and a couple of sleep-disorder markers, plus GWAS Catalog associations for sleep/circadian traits.

What it looks at

  • Caffeine & sleep — CYP1A2 (rs762551), ADORA2A (rs5751876)
  • Sleep quality — MEIS1, BTBD9 (restless-legs / periodic-limb-movement markers)
  • Sleep disorders — an HLA-region marker (rs2858884)
  • Sleep/circadian GWAS associations — your variants matched against GWAS Catalog sleep terms (sleep duration, insomnia, chronotype / morningness, …)

What you'll see

A level per pathway (Elevated / Moderate / Standard), per-SNP genotypes and effects, and a CYP1A2 caffeine-metaboliser read (rapid / intermediate / slow), which cross-references pharmacogenomics.

Good to know

  • Chronotype / morningness are not scored as a dedicated pathway — they surface only indirectly through the GWAS Catalog sleep/circadian term matches above. (A dedicated chronotype pathway was dropped because its only marker was the PER3 54-bp VNTR, which consumer SNP arrays do not type and no validated array-typeable tag SNP replaces.)
  • The HLA-region marker is not a validated proxy for the narcolepsy allele (HLA-DQB1*06:02), so no narcolepsy risk is inferred — that needs direct HLA typing.
  • The CYP1A2 marker reports caffeine metabolism only; it is not a full star-allele call.