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Skin health & pigmentation

Not a medical test — for research and educational use only

Yeliztli analyses consumer genotyping-array data (23andMe / AncestryDNA), which is not a clinical-grade test. Results are not diagnostic, are not clinically validated, and must not be used to make medical decisions. Array data is especially unreliable for rare, disease-causing variants. Always confirm any finding with an accredited clinical laboratory and discuss it with a qualified clinician or genetic counsellor before acting on it. See the Intended use & disclaimers page for the details and the evidence behind this warning.

The skin module gives a categorical read on pigmentation and UV response, skin-barrier function, oxidative aging, and skin-related micronutrients.

What it looks at

  • Pigmentation & UV response — MC1R (multiple red-hair/UV-sensitivity variants)
  • Skin barrier & inflammation — FLG (R501X)
  • Oxidative stress & aging — GSTP1, MMP1, SOD2
  • Skin micronutrients — VDR (vitamin-D signalling)

What you'll see

A level per pathway (Elevated / Moderate / Standard) and per-SNP findings. MC1R is aggregated across its variants into a UV-sensitivity read (low / moderate / high), and cross-links to the cancer module's melanoma context.

Good to know

  • The single FLG variant typed here is flagged insufficient data — comprehensive filaggrin assessment needs sequencing, not a single array position.
  • Weak (1-star) variants are capped at Moderate, and strand-ambiguous palindromic SNPs are withheld as Indeterminate.
  • VDR associations with skin outcomes are inconsistent in the literature, so they're treated as research-grade context.