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Gene fitness

Not a medical test — for research and educational use only

Yeliztli analyses consumer genotyping-array data (23andMe / AncestryDNA), which is not a clinical-grade test. Results are not diagnostic, are not clinically validated, and must not be used to make medical decisions. Array data is especially unreliable for rare, disease-causing variants. Always confirm any finding with an accredited clinical laboratory and discuss it with a qualified clinician or genetic counsellor before acting on it. See the Intended use & disclaimers page for the details and the evidence behind this warning.

The fitness module gives a categorical read on exercise-related traits. Individual genetic effects on athletic performance are small and non-deterministic — treat this as interesting context, not destiny.

What it looks at

8 SNPs across four pathways:

  • Endurance — PPARGC1A, AMPD1, and the well-known ACTN3 R577X
  • Power — ACTN3, MCT1
  • Recovery & injury — COL5A1, COL1A1 (connective-tissue)
  • Training response — FTO
  • An ACE insertion/deletion proxy (rs4341)

What you'll see

A level per pathway (Elevated / Moderate / Standard), with per-SNP findings. ACTN3 is reported with its familiar three-state call (RR / RX / XX), and the ACE proxy carries a caveat.

Good to know

  • The ACE I/D variant isn't directly on the array — it's inferred from a nearby proxy SNP, and that proxy's accuracy varies by ancestry.
  • Weak (1-star) variants are capped at Moderate, and strand-ambiguous palindromic SNPs are marked indeterminate and left out of the pathway level.
  • Sport-specific genetic associations are heterogeneous; these variants predict very little about any one person.