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MTHFR & methylation

Not a medical test — for research and educational use only

Yeliztli analyses consumer genotyping-array data (23andMe / AncestryDNA), which is not a clinical-grade test. Results are not diagnostic, are not clinically validated, and must not be used to make medical decisions. Array data is especially unreliable for rare, disease-causing variants. Always confirm any finding with an accredited clinical laboratory and discuss it with a qualified clinician or genetic counsellor before acting on it. See the Intended use & disclaimers page for the details and the evidence behind this warning.

A deeper dive into MTHFR and the methylation cycle — the biochemistry that recycles folate and methyl groups — across five pathways and roughly 35 SNPs.

What it looks at

  • Folate & MTHFR (MTHFR C677T/A1298C, DHFR, SLC19A1, TCN2, …)
  • Methionine cycle (MTR, MTRR, AHCY, BHMT, …)
  • Transsulfuration (CBS, CTH, GPX1, SOD2, …)
  • BH4 & neurotransmitter synthesis (COMT, VDR, GCH1, MTHFD1, …)
  • Choline & betaine (PEMT, CHDH, FMO3, …)

What you'll see

A level for each of the five pathways (Elevated / Moderate / Standard), per-SNP findings for non-standard genotypes, and an MTHFR compound-heterozygosity assessment (for example carrying C677T and A1298C together).

Good to know

  • Weak (1-star) variants are capped at Moderate; Elevated needs at least 2-star evidence plus a meaningful genotype.
  • Multiple Moderate findings in a pathway are shown as context — they're not added up into an Elevated call.
  • MTHFR variants are common and most people with them are perfectly healthy; treat this as background biochemistry, not a diagnosis.