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Yeliztli Yeliztli

Yeliztli

Yeliztli is a privacy-first personal-genomics analysis platform that runs entirely on your own machine. Upload the raw data file from a consumer genotyping service (23andMe or AncestryDNA), and Yeliztli annotates your variants against public clinical and population databases and organises the results into focused analysis modules — pharmacogenomics, ancestry, carrier status, hereditary-risk panels, wellness traits, and more.

Your genome never leaves your computer: Yeliztli runs on localhost with no cloud processing and no outbound variant data — your genotypes are never uploaded. It does make a few non-genomic connections by default (such as an app-version check); see Privacy & data handling for the complete accounting.

The Yeliztli dashboard, showing the analysis-module overview for a loaded sample

The dashboard — a loaded sample with its analysis modules. (Shown with a synthetic test sample; no real genetic data.)

Read this first — not medical advice

Yeliztli is for research and educational use only. It analyses consumer genotyping-array data, which is not a clinical-grade test: results are not diagnostic and are not clinically validated. Do not make medical decisions based on them. Please read Intended use & disclaimers before you begin.

What you can do with it

  • Annotate your variants against ClinVar, gnomAD, dbNSFP, VEP, ENCODE, and more.
  • Explore every variant in an interactive table and an embedded genome browser.
  • Review findings across many analysis modules, each with an evidence rating and source citations.
  • Build custom queries (visual or SQL) and export to VCF, TSV, CSV, JSON, or FHIR R4.
  • Generate PDF reports for the findings you choose.

Everything is opt-in, and the most sensitive modules require an explicit acknowledgement before any result is shown.

How this documentation is organised

This site is layered so you can read only the parts you need:

  • Getting started — install Yeliztli, upload your DNA, and understand your results. (Start here if you just want to use the app.)
  • Modules & Features — what each analysis module reports and how to read it, plus the variant explorer, genome browser, query builder, reports, and export.
  • Install & self-host — deeper installation, configuration, reference-data, and troubleshooting reference for running your own instance.
  • Develop — architecture and contributor guide for working on Yeliztli itself.
  • Maintainer — operator runbooks for building and releasing the reference-data bundles.

Documentation in progress

This site is being built out section by section. Until every page is published, the project README remains the quickest route to installation and an up-to-date feature list.

Privacy & licensing

  • Yeliztli keeps all processing local — see Privacy.
  • Yeliztli is open source under the MIT license. It bundles and annotates against several public datasets, each retained under its own license.