Metabolic (type-2 diabetes & obesity)

Not a medical test — for research and educational use only

Yeliztli analyses consumer genotyping-array data (23andMe / AncestryDNA), which is not a clinical-grade test. Results are not diagnostic, are not clinically validated, and must not be used to make medical decisions. Array data is especially unreliable for rare, disease-causing variants. Always confirm any finding with an accredited clinical laboratory and discuss it with a qualified clinician or genetic counsellor before acting on it. See the Intended use & disclaimers page for the details and the evidence behind this warning.

The metabolic module estimates polygenic risk for type-2 diabetes and for BMI/obesity, and reports a few well-established anchor variants.

What it looks at

• Polygenic scores: type-2 diabetes (PGS000713) and a multi-ancestry BMI score (PGS005198).
• Anchor SNPs: TCF7L2 (rs7903146), FTO (rs9939609), MC4R (rs17782313) — the best-known common variants for these traits.

What you'll see

• Polygenic findings with the coverage fraction (how many of the score's variants your array actually typed) and whether that's sufficient. Because consumer arrays aren't imputed, typical coverage is only ~35–60%, so the percentile is withheld and the coverage is reported instead.
• Anchor-SNP findings with your genotype and a strand-harmonised dosage, marked indeterminate when a palindromic variant can't be resolved.

Good to know

• These are research-use estimates, not predictions — most of your metabolic risk comes from lifestyle and environment, not these variants.
• An ancestry-mismatch warning is shown when your inferred ancestry differs from the score's source population.