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Gene Detail

Not a medical test — for research and educational use only

Yeliztli analyses consumer genotyping-array data (23andMe / AncestryDNA), which is not a clinical-grade test. Results are not diagnostic, are not clinically validated, and must not be used to make medical decisions. Array data is especially unreliable for rare, disease-causing variants. Always confirm any finding with an accredited clinical laboratory and discuss it with a qualified clinician or genetic counsellor before acting on it. See the Intended use & disclaimers page for the details and the evidence behind this warning.

The Gene Detail page brings together sample variants and cached public gene context for one gene. Open it from a gene symbol in the Findings Explorer, a dashboard finding, or the Protein tab on a variant detail page. Its URL is /genes/{symbol} for the selected sample.

What it shows

  • Protein viewer -- UniProt accession, sequence length, cache status, and a Nightingale diagram of protein domains and features. Protein-changing sample variants with HGVS p. notation can be highlighted on the protein map.
  • Variants -- the sample's annotated variants in the gene, including rsID, HGVS protein notation, consequence, genotype, ClinVar significance and review stars, evidence-conflict status, gnomAD allele frequency, and CADD. Variant IDs link back to their variant detail pages.
  • Population allele frequencies -- a gnomAD subpopulation chart for the gene's variants when population frequency fields are available.
  • Phenotypes -- local gene-phenotype records, including MONDO/HPO/OMIM links when those references are available.
  • Literature -- PubMed article cards from the local literature cache and optional enrichment setup.

Network and privacy note

Opening this page is local for your sample data, but the protein viewer can make one outbound lookup. Yeliztli checks the local UniProt cache first; on a cache miss or stale cache entry, it requests reviewed human protein annotations from rest.uniprot.org/uniprotkb using the gene symbol you are viewing.

That request does not send your genotypes, variants, sample ID, or findings, but it does reveal the inspected gene symbol, your IP address, and the request timing to UniProt/EBI. Results are cached locally in reference.db for 30 days. If the request fails or network access is blocked, Yeliztli shows stale cached protein data when available, or a message that protein data is unavailable.

If you configured PubMed enrichment with a contact email, the Literature section can also search NCBI PubMed for the viewed gene and fetch matching article metadata by PMID. Without that email, Yeliztli uses cached literature only. PubMed requests send public identifiers and NCBI contact metadata, not your genotypes, sample ID, or findings.

See Privacy & data handling for the full network accounting.