Cardiovascular

Not a medical test — for research and educational use only

Yeliztli analyses consumer genotyping-array data (23andMe / AncestryDNA), which is not a clinical-grade test. Results are not diagnostic, are not clinically validated, and must not be used to make medical decisions. Array data is especially unreliable for rare, disease-causing variants. Always confirm any finding with an accredited clinical laboratory and discuss it with a qualified clinician or genetic counsellor before acting on it. See the Intended use & disclaimers page for the details and the evidence behind this warning.

The cardiovascular module screens a 16-gene panel for pathogenic variants linked to inherited heart and lipid conditions, and summarises familial-hypercholesterolemia status.

What it looks at

• Familial hypercholesterolemia (FH): LDLR, PCSK9, APOB
• Other lipid metabolism: LPA, ABCG5, ABCG8
• Channelopathies (arrhythmia syndromes): KCNQ1, SCN5A, KCNH2, RYR2
• Cardiomyopathies: MYBPC3, MYH7, TNNT2, LMNA, DSP, PKP2

What you'll see

• Per-variant findings — ClinVar Pathogenic/Likely-Pathogenic variants with review stars, accession, inheritance pattern, an evidence rating, and the relevant cardiovascular category.
• An FH status summary — Positive or Negative, listing the affected genes and the strongest evidence found.

For recessive conditions, you're told whether you're a carrier or affected, based on how many copies you carry.

Good to know

• A negative result doesn't exclude these conditions — the panel types specific variants, not full gene sequences.
• The dedicated familial-hypercholesterolemia view builds on these findings and adds an LDL-C polygenic score for a fuller FH picture.