Skip to content

Allergy & immune sensitivities

Not a medical test — for research and educational use only

Yeliztli analyses consumer genotyping-array data (23andMe / AncestryDNA), which is not a clinical-grade test. Results are not diagnostic, are not clinically validated, and must not be used to make medical decisions. Array data is especially unreliable for rare, disease-causing variants. Always confirm any finding with an accredited clinical laboratory and discuss it with a qualified clinician or genetic counsellor before acting on it. See the Intended use & disclaimers page for the details and the evidence behind this warning.

The allergy module gives a categorical read on atopic tendencies, certain drug hypersensitivities, food sensitivity (celiac), and histamine metabolism. Several markers are HLA proxies — nearby SNPs that stand in for HLA types an array can't read directly.

What it looks at

  • Atopic conditions — IL13, ORMDL3, STAT6
  • Drug hypersensitivity — proxies for HLA-B*57:01, HLA-B*15:02, HLA-A*31:01, HLA-B*58:01
  • Food sensitivity (celiac) — HLA-DQ2 / DQ8 proxies
  • Histamine metabolism — AOC1, HNMT

What you'll see

A level per pathway, individual SNP findings, a combined celiac read (with a strong rule-out framing), and a combined histamine read. HLA proxy results display an ancestry-specific r² so you can judge their reliability. Findings cross-reference pharmacogenomics (drug reactions) and nutrigenomics (gluten).

Good to know

  • HLA proxies are ancestry-dependent. A negative proxy result is not exclusionary when your ancestry is unknown or the proxy is weak in your population.
  • The celiac DQ2/DQ8 proxies have high negative predictive value but low positive predictive value — ~30–40% of people carry them, yet only ~1% develop celiac disease.
  • Histamine-metabolism evidence is preliminary (candidate-gene level).